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doi: 10.1002/jmri.22501 188 NeugartenJGolestanehL

This is followed by a subsequent reduction by superoxide molecule of the MPO Compound III to produce a hydroxylated enzyme similar to P450, where superoxide is bound to ferrous MPO to interact with the substrate [84]

[1] Because it does not require oxygen , glycolysis played a crucial role during the first two billion years of lifes evolution, representing one of the earliest biological mechanisms for energy extraction from organic molecules